Exposure estimates to disinfection by-products of chlorinated drinking water.

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Exposure estimates to disinfection by-products of chlorinated drinking water.

Exposure to disinfection by-products (DBPs) of drinking water is multiroute and occurs in households serviced by municipal water treatment facilities that disinfect the water as a necessary step to halt the spread of waterborne infectious diseases. Biomarkers of the two most abundant groups of DBPs of chlorination, exhaled breath levels of trihalomethanes (THMs) and urinary levels of two haloac...

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Multivariate distributions of disinfection by-products in chlorinated drinking water.

Drinking water disinfection by-product (DBP) occurrence research is important in supporting risk assessment and regulatory performance assessment. Recent DBP occurrence surveys have expanded their scope to include non-regulated priority DBPs as well as regulated DBPs. This study applies a Box-Cox transformed multivariate normal model and data augmentation methods for left-censored and missing o...

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Exposure to drinking water disinfection by-products and pregnancy loss.

Previous research has suggested that exposure to elevated levels of drinking water disinfection by-products (DBPs) may cause pregnancy loss. In 2000-2004, the authors conducted a study in three US locations of varying DBP levels and evaluated 2,409 women in early pregnancy to assess their tap water DBP concentrations, water use, other risk factors, and pregnancy outcome. Tap water concentration...

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Urinary excretion half life of trichloroacetic acid as a biomarker of exposure to chlorinated drinking water disinfection by-products.

AIMS To measure accurately urinary elimination half life of trichloroacetic acid (TCAA). METHODS A longitudinal pilot exposure/intervention study measured the elimination half life of TCAA in urine. Beverage consumption was limited to a public water supply and bottled water of known TCAA concentration, and ingestion volume was managed. The five participants limited fluid consumption to only t...

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Validation of urinary trichloroacetic acid as a biomarker of exposure to drinking water disinfection by-products.

Disinfection by-products (DBPs) in drinking water represent a public health issue and a challenge for epidemiology to provide evidence towards the causation of various hypothesized health effects. Validation of a biomarker of exposure to DBPs is a strategy to achieve progress which has been advocated. The objective of this study was to validate urinary trichloroacetic acid (TCAA) excretion as a...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1999

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.99107103